Effect of Coronary Blood Flow

Myocardial uptake and washout of thallium-201 (20TI) were studied in an experimental dog model in which regional blood flow to the posterior wall was varied by transient 2-minute occlusion of the circumflex coronary artery to produce transient ischemia and reactive hyperemia. Thallium-201 myocardial activity in a region of interest was determined continuously after i.v. administration by a gamma camera and computer program. Activity in the posterior wall was compared with that in the anterior wall in the same dog and the posterior wall of control dogs. Thallium-201 uptake was directly related to blood flow. With reactive hyperemia, there was a rapid and absolute increase in uptake followed by rapid washout; with ischemia, there was slow and decreased uptake followed by a slow washout. The calculated myocardial activity during washout in both ischemic and hyperemic areas approached values in control dogs long after blood flow had returned to baseline levels. Significant differences in washout slopes were found between the three groups of dogs (-0.156%/min in control dogs, -0.244%/min after reactive hyperemia, and -0.076%/min after transient ischemia, with half-washout times of 5.3 hours, 3.4 hours and 11.0 hours, respectively). These data suggest that both the initial decrease in activity in the ischemic area and the initial excess in the hyperemic area are corrected by different washout rates of ischemic and hyperemic cells during redistribution.